The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.
The Institute of Neuropathology at University of Muenster, Germany, is offering at the earliest opportunity limited to 3 years a position as a
PhD Candidate (gn*)
as Early Stage Researcher in the Marie Skłodowska-Curie Initial Training Network PMSMatTrain
(e.g. biology, chemistry, biochemistry, biotechnology)
Applications are invited from suitably qualified candidates for one full-time fixed term position as Early Stage Researchers with the Institute of Neuropathology at the University Hospital Münster, Germany. The candidate will join the group of Prof. Dr. med. Tanja Kuhlmann. The researcher will develop and validate the therapeutic efficacy of a novel device housing a multi-modal hydrogel using iPSC derived in vitro models of multiple sclerosis (MS). Outputs from the research will inform in vivo studies and imaging modalities and will aid the generation of in silico models of the circulation of therapeutics within the cerebrospinal fluid.
The position is funded by the Horizon 2020 programme of the European Union and is available from April 2020. The appointment will be on a temporary basis for a maximum period of 3 years (regular full-time employment contract).
PMSMatTrain is a four-year project, funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement No. 813263. The project focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs). This multidisciplinary network will educate and train 15 Early Stage Researchers in device design, biomaterials, materials science, stem cell biology, in vitro, ex vivo and in vivo models of multiple sclerosis, molecular biology, in silico modelling of CSF flow, material functionalisation strategies and device validation.
Programme fellows will experience both public and private sector research & development training and will be best placed to secure employment as high calibre, innovative and well-trained graduates.
Duties and Responsibilities:
The successful candidate will
- Develop an in vitro MS model using human iPSC technology
- Assess the bioactivity and efficacy of compounds released from the multi-modal scaffolds on 2D and 3D in vitro assays.
- Establish an MS in vivo model and assess the bioactivity and efficacy of compounds released from the multi-modal scaffolds
- In collaboration with other consortium researchers, investigate the efficacy of this multimodal scaffolds in different in vivo models of multiple sclerosis using state-of-the art imaging technologies and proteomic approaches.
- Develop protocols for the scale up of the optimised device in collaboration with research fellows in the private sector.
- Participate in training events for researchers and Principal Investigators involved in the programme.
- Liaise and report to the Project Manager, which includes contributing to periodic scientific reports.
- Contribute to the reporting of project milestones and deliverables in accordance with EU deadlines.
- Promote and disseminate results from the programme, which includes contributing to newsletters and participating in outreach events
- Master’s degree or equivalent in live science like biology, chemistry, biochemistry, biotechnology.
- Less than 4 years' full time-equivalent research experience and not yet have been awarded a doctoral degree (PhD)
- Resided less than 12 months in Germany in the last 3 years.
- Excellent knowledge in animal models and cell culture techniques
- Excellent communication and organisation skills
- Fluent in spoken and written English
- Excellent writing and presentation skills
- Flexibility and ability to work in a team environment
- A keen interest in pursuing translational research in multiple sclerosis
- Experience with MS animal models
For information on moving to Germany, please see www.euraxess.ie.
Applications (in English) should include a CV (Please use the Europass template: https://europass.cedefop .europa.eu/editors/en/cv/compose), certificates of examination grades, a motivation letter (max. one page) describing your research career goals, skills and experience, as well as two letters of recommendation. Please send applications by e-mail (in PDF only) to Bewerbung(at)ukmuenster(dot)de. Please quote the reference number 04285.
Applications from female candidates are particularly encouraged. In the case of equal qualifications, competence and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities unless reasons specific to an individual male candidate predominate. Handicapped candidates with equal qualifications will be given preference.
This project has been funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement No. 813263