Email: Silke Niemann
Our group works on different aspects of Staphylococcus aureus pathogenesis. S. aureus is an extreme versatile pathogen that can not only colonize epithelial surfaces, but can also induce different kinds of infections, including very serious infections such as endocarditis, osteomyelitis, soft tissue infections and pneumonia. To establish an infection S. aureus needs to adhere to host structures and invade host cells. In different projects we investigate bacterial factors that are required for adherence and invasion of mammalian cells. Furthermore, we analyse, which bacterial products (toxins, enzymes, peptides, wall-components) induce inflammatory reactions and cytotoxic effects in the host. However, S. aureus does not only harm and kill host cells, but can also persist intracellularly for long time periods.