Publikationen

Hoerr V, Franz M, Pletz MW, Diab M, Niemann S, Faber C, Doenst T, Schulze PC, Deinhardt-Emmer S and Loffler B.
S. aureus endocarditis: Clinical aspects and experimental approaches.
Int J Med Microbiol. 2018 Aug;308(6):640-652. doi: 10.1016/j.ijmm.2018.02.004. Epub 2018 Feb 21. Review

van Kruchten A, Wilden JJ, Niemann S, Peters G, Loffler B, Ludwig S and Ehrhardt C.
Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death.
FASEB J. 2018 May;32(5):2779-2793. doi: 10.1096/fj.201701006R. Epub 2018 Jan 11.

Niemann S, Bertling A, Brodde MF, Fender AC, Van de Vyver H, Hussain M, Holzinger D, Reinhardt D, Peters G, Heilmann C, Loffler B and Kehrel BE.
Panton-Valentine Leukocidin associated with S. aureus osteomyelitis activates platelets via neutrophil secretion products.
Sci Rep. 2018 Feb 1;8(1):2185. doi: 10.1038/s41598-018-20582-z.

Bruchhagen C, Jarick M, Mewis C, Hertlein T, Niemann S, Ohlsen K, Peters G, Planz O, Ludwig S and Ehrhardt C.
Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound.
Sci Rep. 2018 Jun 14;8(1):9114. doi: 10.1038/s41598-018-27445-7.

Van de Vyver H, Bovenkamp PR, Hoerr V, Schwegmann K, Tuchscherr L, Niemann S, Kursawe L, Grosse C, Moter A, Hansen U, Neugebauer U, Kuhlmann MT, Peters G, Hermann S and Loffler B.
A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection: Noninvasive Imaging of Biofilm Development in Vivo.
Am J Pathol. 2017 Feb;187(2):268-279. doi: 10.1016/j.ajpath.2016.10.005. Epub 2017 Jan 11.

Lebughe M, Phaku P, Niemann S, Mumba D, Peters G, Muyembe-Tamfum JJ, Mellmann A, Strauss L and Schaumburg F.
The Impact of the Staphylococcus aureus Virulome on Infection in a Developing Country: A Cohort Study.
Front Microbiol. 2017 Aug 29;8:1662. doi: 10.3389/fmicb.2017.01662. eCollection 2017.

Klemm C, Bruchhagen C, van Kruchten A, Niemann S, Loffler B, Peters G, Ludwig S and Ehrhardt C.
Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection.
Sci Rep. 2017 Feb 14;7:42473. doi: 10.1038/srep42473.

Gruner MC, Niemann S, Faust A and Strassert CA.
Axially Decorated Si(IV) -phthalocyanines Bearing Mannose- or Ammonium-conjugated Siloxanes: Comparative Bacterial Labeling and Photodynamic Inactivation
Photochem Photobiol. 2017 Dec 29. doi: 10.1111/php.12881. [Epub ahead of print]

Wang J, Morita Y, Han B, Niemann S, Loffler B and Rudolph KL.
Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.
Nat Cell Biol. 2016 May;18(5):480-90. doi: 10.1038/ncb3342. Epub 2016 Apr 18.

Strobel M, Pfortner H, Tuchscherr L, Volker U, Schmidt F, Kramko N, Schnittler HJ, Fraunholz MJ, Loffler B, Peters G and Niemann S. Post-invasion events after infection with Staphylococcus aureus are strongly dependent on both the host cell type and the infecting S. aureus strain.
Clin Microbiol Infect. 2016 Sep;22(9):799-809. doi: 10.1016/j.cmi.2016.06.020. Epub 2016 Jul 5.

Galstyan A, Block D, Niemann S, Gruner MC, Abbruzzetti S, Oneto M, Daniliuc CG, Hermann S, Viappiani C, Schafers M, Loffler B, Strassert CA and Faust A.
Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts.
Chemistry. 2016 Apr 4;22(15):5243-52. doi: 10.1002/chem.201504935. Epub 2016 Mar 1. Erratum in: Chemistry. 2016 Jun 27;22(27):9051.

Warnking K, Klemm C, Loffler B, Niemann S, van Kruchten A, Peters G, Ludwig S and Ehrhardt C.
Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization.
Cell Microbiol. 2015 Mar;17(3):303-17. doi: 10.1111/cmi.12375. Epub 2014 Nov 19.

Tuchscherr L, Bischoff M, Lattar SM, Noto Llana M, Pfortner H, Niemann S, Geraci J, Van de Vyver H, Fraunholz MJ, Cheung AL, Herrmann M, Volker U, Sordelli DO, Peters G and Loffler B.
Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections
PLoS Pathog. 2015 Apr 29;11(4):e1004870. doi: 10.1371/journal.ppat.1004870. eCollection 2015 Apr.

Kalinka J, Hachmeister M, Geraci J, Sordelli D, Hansen U, Niemann S, Oetermann S, Peters G, Loffler B and Tuchscherr L.
Staphylococcus aureus isolates from chronic osteomyelitis are characterized by high host cell invasion and intracellular adaptation, but still induce inflammation.
Int J Med Microbiol. 2014 Nov;304(8):1038-49. doi: 10.1016/j.ijmm.2014.07.013. Epub 2014 Jul 27.

Löffler B, Tuchscherr L, Niemann S, Peters G.
Staphylococcus aureus persistence in non-professional phagocytes.
Int J Med Microbiol. 2013 Dec 1. pii: S1438-4221(13)00184-7. doi: 10.1016/j.ijmm.2013.11.011.

Werdan K, Dietz S, Löffler B, Niemann S, Bushnaq H, Silber RE, Peters G, Müller-Werdan U.
Mechanisms of infective endocarditis: pathogen-host interaction and risk states.
Nat Rev Cardiol. 2014 Jan;11(1):35-50. doi: 10.1038/nrcardio.2013.174. Epub 2013 Nov 19.

Kramko N, Sinitski D, Seebach J, Löffler B, Dieterich P, Heilmann C, Peters G, Schnittler HJ.
Early Staphylococcus aureus-induced changes in endothelial barrier function are strain-specific and unrelated to bacterial translocation.
Int J Med Microbiol. 2013 Dec;303(8):635-44. doi: 10.1016/j.ijmm.2013.09.006. Epub 2013 Sep 7

Kneidl J, Mysore V, Geraci J, Tuscherr L, Löffler B, Holzinger D, Roth J, Barczyk-Kahlert K.
Soluble CD163 masks fibronectin-binding protein A-mediated inflammatory activation of Staphylococcus aureus infected monocytes.
Cell Microbiol. 2013 Oct 11. doi: 10.1111/cmi.12225. [Epub ahead of print]

Löffler B, Niemann S, Ehrhardt C, Horn D, Lanckohr C, Lina G, Ludwig S, Peters G.
Pathogenesis of Staphylococcus aureus nectrotizing pneumonia: the role of PVL and an influenza coinfection.
Expert Rev Anti Infect Ther. 2013 Oct;11(10):1041-51. doi: 10.1586/14787210.2013.827891. Epub 2013 Sep 27.

Kreis CA, Raschke MJ, Roßlenbroich SB, Tholema-Hans N, Löffler B, Fuchs T.
Therapy of intracellular Staphylococcus aureus by tigecyclin.
BMC Infect Dis. 2013 Jun 5;13:267. doi: 10.1186/1471-2334-13-267.

Horst SA, Hoerr V, Beineke A, Kreis C, Tuchscherr L, Kalinka J, Lehne S, Schleicher I, Köhler G, Fuchs T, Raschke MJ, Rohde M, Peters G, Faber C, Löffler B, Medina E.
A Novel Mouse Model of Staphylococcus aureus Chronic Osteomyelitis That Closely Mimics the Human Infection: An Integrated View of Disease Pathogenesis.
Am J Pathol. 2012 Oct;181(4) : 1206-14. doi: 10.1016/j.ajpath.2012.07.005. Epub 2012 Aug 16

Niemann S, Ehrhardt C, Medina E, Warnking K, Tuchscherr L, Heitmann V, Ludwig S, Peters G, Löffler B.
Combined Action of Influenza Virus and Staphylococcus aureus Panton-Valentine Leukocidin Provokes Severe Lung Epithelium Damage.
J Infect Dis. 2012 Oct; 206(7) : 1138-48. Epub 2012 Jul 26

Holzinger D, Gieldon L, Mysore V, Nippe N, Taxman DJ, Duncan JA, Broglie PM, Marketon K, Austermann J, Vogl T, Foell D, Niemann S, Peters G, Roth J, Löffler B.
Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome.
J Leukoc Biol. 2012 Aug 14. [Epub ahead of print]

Stahl O, Löffler B, Haier J, Mardin WA, Mees ST.
Mimicry of human sepsis in a rat model-Prospects and limitations.
J Surg Res. 2012 Apr 1. [Epub ahead of print]

Löffler B.
Staphylococcus-aureus-Adhärenz, Wirtszellinvasion und Persistenz.
Z Herz- Thorax-Gefäßchir. 2012; 26 : 253-258

Kneidl J, Löffler B, Erat MC, Kalinka J, Peters G, Roth J, Barczyk K.
Soluble CD163 Promotes Recognition, Phagocytosis and Killing of Staphylococcus aureus Via Binding of Specific Fibronectin Peptides.
Cell Microbiol. 2012 Jun; 14(6) : 914-36. Epub 2012 Feb 24

Strobel K, Hoerr V, Schmid F, Wachsmuth L, Löffler B, Faber C.
Early detection of lung inflammation: Exploiting T(1) -effects of iron oxide particles using UTE MRI.
Magn Reson Med. 2012 Feb 24. doi: 10.1002/mrm.24180. [Epub ahead of print]

 Tuchscherr L, Medina E, Hussain M, Völker W, Heitmann V, Niemann S, Holzinger D, Roth J, Proctor RA, Becker K, Peters G, Löffler B.
Staphylococcus aureus  phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection.
EMBO Mol Med. 2011 Mar; 3(3) : 129-41

Tuchscherr L, Löffler B, Buzzola FR, Sordelli DO.
Staphylococcus aureus adaptation to the host and persistence: role of loss of capsular polysaccharide expression.
Future Microbiol. 2010 Dec; 5(12) : 1823-32

Nippe N, Varga G, Holzinger D, Löffler B, Medina E, Becker K, Roth J, Ehrchen JM, Sunderkötter C.
Subcutaneous infection with S. aureus in mice reveals association of resistance with influx of neutrophils and Th2 response.
J Invest Dermatol. 2011 Jan; 131(1) : 125-32

Tuchscherr, L., V. Heitmann, M. Hussain, D. Viemann, J. Roth, von Eiff C., K. Becker, G. Peters, and B. Löffler.
2010. Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence, 
J Infect Dis. 2010 Oct 1;202(7):1031-40.

Grundmeier, M., L. Tuchscherr, M. Bruck, D. Viemann, J. Roth, E. Willscher, K. Becker, G. Peters, and B. Löffler. 
Staphylococcal strains vary greatly in their ability to induce an inflammatory response in endothelial cells.
J Infect Dis.2010 15;201 (6) : 871-880.

Löffler, B., M. Hussain, M. Grundmeier, M. Bruck, D. Holzinger, G. Varga, J. Roth, B. C. Kahl, R. A. Proctor, and G. Peters. 
Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils. 
PLoS Pathog. 2010 Jan 8; 6(1): e1000715.

Mennigen, R., K. Nolte, E. Rijcken, M. Utech, B. Löffler, N. Senninger, and M. Bruewer. 
2009. Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. 
Am. J Physiol Gastrointest. Liver Physiol 296:G1140-G1149

Baum, C., B. Haslinger-Löffler, H. Westh, K. Boye, G. Peters, C. Neumann, and B. C. Kahl. 
2009. Non-spa typable clinical Staphylococcus aureus strains are natural occuring protein A mutants. 
J Clin. Microbiol. 2009

Hussain, M., D. Schafer, K. M. Juuti, G. Peters, B. Haslinger-Löffler, P. I. Kuusela, and B. Sinha. 
Expression of Pls (Plasmin Sensitive) in Staphylococcus aureus Negative for pls Reduces Adherence and 
Cellular Invasion and Acts by Steric Hindrance. 
J Infect Dis 2009; 107-117

Haslinger-Löffler, B.
Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function. 
Kidney Int 2008; 74 : 553-555

Haslinger-Löffler, B., M. Brück, M. Grundmeier, G. Peters, and B. Sinha. 2007. 
Staphylococcal infections impair the mesothelial fibrinolytic system: the role of cell death and cytokine release. 
Thromb Haemost 2007; 98 : 813-822

Haslinger-Löffler, B., B. Wagner, M. Brück, K. Strangfeld, M. Grundmeier, U. Fischer, W. Volker, G. Peters, K. Schulze-Osthoff, and B. Sinha. 2006. 
Staphylococcus aureus induces caspase-independent cell death in human peritoneal mesothelial cells. 
Kidney Int. 2006; 70 : 1089-1098

Haslinger-Löffler, B., B. C. Kahl, M. Grundmeier, K. Strangfeld, B. Wagner, U. Fischer, A. L. Cheung, G. Peters, K. Schulze-Osthoff, and B. Sinha. 2005. 
Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. 
Cell Microbiol. 7:1087-1097

Sinha, B., B. Haslinger-Löffler, and K. Schulze-Osthoff.
Caspase-Aktivierung bei Staphylococcus aureus alpha-Toxin-induzierter Apoptose. 
Hygiene und Mikrobiologie 2004; 8 : 20-24

Haslinger, B., K. Strangfeld, G. Peters, K. Schulze-Osthoff, and B. Sinha. 2003. 
Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway. 
Cell Microbiol 2003; 5 : 729-41

Filme aus der Wissenschaft

 

Wandelbare Bakterien

Film herunterladen (640 x 360 Pixel / 57 MB)
Film herunterladen (1280 x 720 Pixel (HD) / 106 MB)

Englische Version des Films herunterladen (640 x 360 Pixel / 57 MB)